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Ghrelin is a 28-amino acid acylated peptide predominantly produced by the stomach. It displays strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptors specific for synthetic GHS. Ghrelin also acts on other central and peripheral receptors and enables other actions including: stimulation of lactotroph and corticotroph secretion; food-intake; gastro-entero-pancreatic functions; metabolic; cardiovascular activity; and anti-proliferative effects. This volume aims to highlight the impact and function of the hormone ghrelin and provide insight to neuroendocrinologies and researchers interested in its molecular and clinical relevance.

Ghrelin

Contents
List of Contributors
Preface

1. Historical Milestones; C.Y. Bowers
2. Discovery of Ghrelin, an Endogenous Ligand for the Growth-Hormone Secretagogue Receptor; M. Kojima, H. Hosoda, H. Kaiya and K. Kangawa
3. Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands; G. Muccioli, F. Broglio, E. Tarabra and E. Ghigo
4. Ghrelin: A New Link Between the Neuroendocrine Control of the GH Axis, Food Intake and Sleep; V. Tolle and the INSERM-ATC Nutrition Research Group on Ghrelin
5. Growth Hormone Releasing Activity of Ghrelin; C. Diéguez, F. Cordido, V. Popovic and F.F. Casanueva
6. Non-Growth Hormone Endocrine Actions of Ghrelin; M. Korbonits and A.B. Grossman
7. Ghrelin Food Intake and Energy Balance; M.H. Tschöp, T. Castaneda and U. Pagotto
8. Cardiovascular Activities of Ghrelin and Synthetic GHS; J. Isgaard, I. Johansson and A. Tivesten
9. Ghrelin: Central Actions and Potential Implications in NeuroDegenerative Diseases; R.G. Smith, Y. Sun, A.R.T. Bailey and A. Paschali
10. Ghrelin and Tumors; M. Papotti, C. Ghe, M. Volante and G. Muccioli
11. Metabolic Actions of Ghrelin; C. Gauna and A.J. van der Lely
12. Gastro-Entero-Pancreatic Actions of Ghrelin; Y. Date, M. Nakazato, K. Kangawa and H. Matsuo
13. A New Interaction to Come: Ghrelin and Steroid Hormones; U. Pagotto, A. Gambineri, V. Vicennati and R. Pasquali
14. Circulating Ghrelin Levels in Pathophysiological Conditions; D.E. Cummings and J. Overduin
15. Ghrelin Measurement: Present and Perspectives; H. Hosoda and K. Kangawa
16. Ghrelin: Implications in Pediatric Endocrinology; S. Bellone, A. Rapa, F. Broglio and G. Bona
17. Ghrelin and its Analogues: Perspectives for a Story of Reverse Pharmacology; E. Ghigo

Index