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Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Mechanisms of Lymphocyte Activation and Immune Regulation VI: Cell Cycle and Programmed Cell Death in the Immune System

Apoptosis/Programmed Cell Death: A Brief Historical Perspective; S. Gupta Cell Cycle and Signaling Pathways in Apoptosis: Apoptosis and Its Regulation; J.J. Cohen Mechanisms for Recognition and Phagocytosis of Apoptotic Lymphocytes by Macrophages; R.A. Schlegel, et al. Cytotoxic Lymphocyte Killing Enters the ICE Age S.J. Martin, et al. Crosstalk between Ceramide and PKC Activity in the Control of Apoptosis in WEHI231; S.J. Chmura, et al. Apoptosisregulating Genes: Regulation of Lymphoid Apoptosis by Bc12 and Bc1xL; G. Nunez, et al. The Epstein-Barr Virus Gene BHRF1, a Homologue of the Cellular Oncogene bcl2, Inhibits Apoptosisinduced by Gamma Radiation and Chemotherapeutic Drugs; N.J. McCarthy, et al. Structure-Function Analysis of Bcl2 Family Proteins: Regulators of Programmed Cell Death; J.C. Reed, et al. Role of ICE-proteases in Apoptosis; V.M. Dixit Fas-mediated Apoptosis; S. Nagata Apoptosis in B Cells: Signals for Survival and Apoptosis in Normal and Neoplastic B Lymphocytes; J. Gordon, et al. Regulation of B Cell Apoptosis R.F. Ashman, et al. Apoptotic Cell Death in the Chicken Bursa of Fabricius; K.A. Jacobsen, et al. Apoptosis in T Cells: The Thymus and T Cell Death; J. Sprent, et al. Genetic Regulation of Apoptosis in the Mouse Thymus; B.A. Osborne, et al. Regulation of T Cell Activation by CD28 and CTLA4; P.J. Noel, et al. 8 additional articles. Index.