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We anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists.

We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.

Adrenocortical Carcinoma: Basic Science and Clinical Concepts

Preface1. History of ACC Research and Clinical Care1.1. ACC - A 50 year retrospective view1.2. History of ACC Treatment - A Surgical Perspective2. Epidemiology, Presentation and Diagnosis2.1. Epidemiology2.2. Presentation and Diagnosis2.3. Approach to the Adrenal incidentaloma3.0. Imaging3.1. Anatomic imaging3.2. Functional imaging4. Pathology4.1. ACC Histopathology4.2. Molecular and Cellular Pathology5. Genetic & Molecular Aspects of ACC5.1. Overview of the Genetics of ACC5.2. Li Fraumeni Syndrome5.3. P53 Molecular Genetics5.4. Telomeres and ACC5.5. Beckwith Wiedemann Syndrome5.6. Insulin-like growth Factors5.7. Wnt signaling6. Models of Adrenocortical Cancer6.1. Cellular origin and identity of ACC6.2. Adrenocortical cell lines6.3. Mouse Models of Adrenal Tumorigenesis7. Therapies7.1. Introduction7.2. Mitotane7.3. Cytotoxic Chemotherapy7.4. Steroidogenesis and Therapy of Hormone Excess7.5. Surgical therapy7.6. Radiation Therapy7.7. Surveillance and follow up of ACC8 Unique ACC Cohorts and Future Perspectives8.1.. Aldosterone producing ACC8.2. Childhood ACC8.3. Molecular Profiling of Adrenal Cancer8.4. Clinical Registries: Dutch and European experiences8.5. Emerging Strategies