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This book covers in detail contemporary hypotheses and studies related to the immunology of implantation and provides a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR. Provides complete and up to date review of current knowledge of the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system.

Immunology of Pregnancy

Evolution of the Mammalian Reproductive Tract and Placentation.- Toll-Like Receptors and Pregnancy.- IL-10 and Pregnancy.- Th1/Th2 Balance of the Implantation Site in Humans.- The Regulation of Human Trophoblast Apoptosis and Survival during Pregnancy.- Macrophages and Pregnancy.- Potential Role of Glucocorticoids in the Pathophysiology of Intrauterine Growth Restriction (IUGR).- NK Cells and Pregnancy.- The Role of Corticotropin-Releasing Hormone (CRH) on Implantation and Immunotolerance of the Fetus.- Indoleamine 2,3 Dioxygenase-Dependent T Cell Suppression and Pregnancy.- Leukemia Inhibitory Factor in Reproduction.- Characterization of Human Dendritic Cells at the Materno-Fetal Interface.- MHC Molecules of the Preimplantation Embryo and Trophoblast.- Actions of Seminal Plasma Cytokines in Priming Female Reproductive Tract Receptivity for Embryo Implantation.- B7 Family Molecules in the Placenta.- The Role of Regulatory T Cells in Materno-Fetal Tolerance.- The Eutherian Fetoembryonic Defense System Hypothesis: An Update.- The Nature and Role of the Decidual T Cells.- Trophoblast Cells as Immune Regulators.- Inherited Thrombophilias and Early Pregnancy Loss.- Bi-Directional Cell Trafficking during Pregnancy.- Term and Preterm Parturition.- Interleukin-1 and Implantation.- Immunology and Pregnancy Losses.