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In this book, leading-edge investigators offer effective strategies to improve current antidepressive therapies and suggest molecular, biological, and genetic approaches that will lead to the development of novel antidepressants. The contributors' critical reviews and commentaries illuminate our understanding of the mechanism(s) responsible for antidepressant action. The book's goal is to move beyond current biogenic amine-based concepts and therapies to the development of new and improved antidepressants that are more effective and have a more rapid onset than current. In Antidepressants: Current Trends and Future Directions, leading-edge investigators distill the dramatic recent advances in our understanding of the mechanisms responsible for antidepressant action. The authoritative contributors offer strategies to improve current therapies grounded on biogenic amine-based concepts. By departing from traditional strategies, the authors offer alternatives to therapies that often work too slowly or not at all, and suggest how the many recent advances in molecular biology and genetics might best be exploited in the design of optimal new therapies.
Antidepressants: Current Trends and Future Directions summarizes novel concepts of antidepressant therapy that attempt to exploit provocative new insights from the laboratory to improve current, biogenic amine-based therapies. Readers will find the book an exceptional resource in opening the door to the development of newer and more effective antidepressant therapies.

Antidepressants: New Pharmacological Strategies

Strategies to Optimize the Antidepressant Action of Selective Serotonin Reuptake Inhibitors, Luz Romero, Josep M. Casanovas, Ildefons Hervás, Roser Cortés, and Francesc Artigas. Antidepressant Properties of Specific Serotonin-Noradrenaline Reuptake Inhibitors, Michael Briley and Chantal Moret. 5-HT Moduline: Novel Therapeutic Strategy for Antidepressant Action, Gilles Fillion, Laure Seguin, Olivier Massot, Jean-Claude Rousselle, Marie-Paule Fillion, Isabelle Cloëz-Tayarani, Brigitte Grimaldi, Jean-Christophe Seznec, and Nicole Prudhomme. Reversible Inhibitors of Monoamine Oxidase A (RIMAs): Where Can We Go from Here? Vivette Glover. Calcium Channel Antagonists in Mood Disorders, Olgierd Pucilowski. Functional NMDA Antagonists: A New Class of Antidepressant Agents, Ramon Trullas. Is an Adaptation of NMDA Receptors an Obligatory Step in Antidepressant Action? Nuo-Yu Huang, Richard T. Layer, and Phil Skolnick. NMDA Receptors and Affective Disorders, Ian A. Paul. The Potential Contribution of Sigma Receptors to Antidepressant Actions, Brian E. Leonard. A Role for CREB in Antidepressant Action, Ronald S. Duman, Masashi Nibuya, and Vidita A. Vaidya. Antidepressants: Beyond the Synapse, S. Paul Rossby and Fridolin Sulser. Animal Models to Detect Antidepressants: Are New Strategies Necessary to Detect New Agents? Paul Willner and Mariusz Papp. Molecular Strategies to Novel Antidepressant Discovery, Steven M. Paul, Xin Wu, Yanbin Liang, and Edward I. Ginns. Index.