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Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics. After more than 50 years of limited success in controlling blood pressure with traditional antihypertensive drugs, the time is ripe to explore alternate strategies for managing cardiovascular diseases. In Cardiovascular Genomics, recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. They involve genetic linkage analysis and substitution mapping using congenic strains, microarray techniques, and strategies for discovery in animal models of hypertension. The new transgenic mouse models that either over- or underexpress angiotensinogen are used to illuminate the function of the tissue renin-angiotensin systems, enhancing the understanding of the role of polymorphisms, a crucial factor for effective design of new drugs. The chapters on gene transfer and gene therapy cover a wide variety of topics ranging from novel clinical applications for treating stroke, coronary, and peripheral vascular diseases, to producing new cardiovascular cells and tissues, to using viral vectors as tools. A value-added compact disk containing a companion ebook version of Cardiovascular Genomics is included for downloading and use in the reader's PC or PDA.
Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both cutting-edge scientific approaches through the new science of cardiovascular genomics, and the efficacious results it is now possible to obtain.

Cardiovascular Genomics

Part I. Genes and Polymorphisms in Cardiovascular Disease

Angiotensin II Receptor Polymorphisms and Hypertension
Bruno Baudin

Angiotensinogen Gene Polymorphisms and Hypertension
Ashok Kumar

Substitution Mapping: Using Congenic Strains to Detect Genes Controlling Blood Pressure
Bina Joe and Michael R. Garrett

Local Production of Angiotensinogen: Insights From Genetic Manipulation of Mice
Kamal Rahmouni and Curt D. Sigmund

Cardiovascular Pharmacogenomics
Julie A. Johnson and Larisa H. Cavallari

Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitors
Anke-Hilse Maitland-van der Zee, Olaf H. Klungel, and Anthonius de Boer

Monogenic Causes of Heart Failure: Familial Dilated Cardiomyopathy
Hideko Kasahara

Part II. Gene Transfer for Combating Cardiovascular Disease

Gene Therapy vs Pharmacotherapy
Ryuichi Morishita

Molecular Therapeutic Approaches for Myocardial Protection
Alok S. Pachori, Luis G. Melo, and Victor J. Dzau

Gene Transfer and the Cardiovascular System
William H. Miller, Stuart A. Nicklin, Andrew H. Baker, and Anna F. Dominiczak

Kallikrein Gene Transfer in Hypertension, Cardiovascular and Renal Disease, and Stroke
Julie Chao and Lee Chao

Current and Future Novel Targets of Gene Therapy for Hypertension
Michael J. Katovich, Justin L. Grobe, and Mohan K. Raizada

Application of Viral Gene Transfer in Studies of Neurogenic Hypertension
Sergey Kasparov, A. G. Teschemacher, and Julian F. R. Paton

Vigilant Vectors: Intelligent Gene Vectors for Cardioprotection in Myocardial Ischemia
M. Ian Phillips and Yi Tang

Gene Therapy for Cerebral Arterial Diseases
Yoshimasa Watanabe and Donald D. Heistad

Part III. Regenerative Tissues for the Diseased Cardiovascular System

Therapeutic Angiogenesis and Vasculogenesis for Tissue Regeneration
Paolo Madeddu

Cell Transplantation: The New Frontier
Shafie Fazel, Paul W. M. Fedak, Richard D. Weisel, Denis Angoulvant, Terrence M. Yau, and Ren-Ke Li

Embryonic Stem Cells and the Cardiovascular System
Neta Lavon and Nissim Benvenisty

Index