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Covering the latest advances in the field, Dopamine in the Treatment of Schizophrenia, Second Edition provides a detailed explanation of the etiology and clinical presentation of the disease, especially as related to the dopamine system. Written by an international team of experts, the text identifies genetic polymorphisms that affect dopaminergic neurotransmission and their possible impact on familial forms of schizophrenia. It also explores the neurophysiological and neurochemical studies of dopaminergic function and the integration of dopamine-containing neurons with other transmitter systems. It reviews imaging studies and their contribution to our understanding of the pathophysiology of schizophrenia and the mechanism of action of antipsychotics. Finally, the book puts the role of dopamine in the context of other brain systems and highlights the many unmet needs of patients, despite best current treatments.

Dopamine In The Patophysiology & Treatment Of Schizophrenia

Historical Aspects and Future Directions

Evidence of Brain Imaging Studies for Dopaminergic Alterations in Schizophrenia

Modulation of Dopamine D^O2

Receptors as a Basis of Antipsychotic Effect

Amisulpride as a Model: Clinical Effects of a Pure Dopaminergic Agent

A Meta-analysis of Studies with the Atypical Antipsychotic Amisulpride

Evidence from Brain Imaging fpr Regional Monoaminergic Specificity in Schizophrenia

Dopamine, the Prefrontal Cortex, and A Genetic Mechanism of Schizophrenia

Models of Schizophrenia: From Neuroplasticity and Dopamine to Psychopathology and Clinical Management

Multiple Neurotransmitters Involved in Antipsychotic Drug Action

Dopaminergic and Glutamatergic Influences in the Systems Biology of Schizophrenia

Pharmacogenomics of Antipsychotic Drugs

Key Issues and Unmet Needs in Schizophrenia

Index