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This book provides a selection of essential knowledge on the image-based quantification of biophysical parameters for the purpose of clinical diagnosis. The authors regard clinical imaging scanners as physical measurement systems capable of quantifying intrinsic parameters for depiction of the constitution and biophysical properties of in vivo tissue. On the one hand, this approach supports the development of new methods of imaging highly reproducible, system-independent, and quantitative biomarkers, and these methods receive detailed attention in the book. On the other hand, the reader will also gain a deeper understanding of how physical tissue properties interact with the generation of signals in medical imaging, opening new windows on the intricate and fascinating relationship between the structure and function of living tissues. The book will be of interest to all who recognize the limitations of basing clinical diagnosis primarily on visual inspection of images and who wish to learn more about the diagnostic potential of quantitative and biophysics-based medical imaging markers and the challenges that the paucity of such markers poses for next-generation imaging technologies.

Quantification of Biophysical Parameters in Medical Imaging

PART I: Tissue properties

1. Sack

Multiscale biophysical interactions and parameters in medical imaging

2. Taupitz

The Extracellular matrix as target for medical imaging

3. Käs

Single cell physical properties and collective behavior in tumors.

4. Hirsch

Biot's theory of biphasic poroelastic media and its application to incompressible tissue

5. &nb

sp; Wall/Caiazzo

Fluid dynamics in living systems

PART II: Imaging technology & data analysis

6. Kutyniok

Mathematical Methods in Medical Image Processing

7. Dewey, Kachelrieß

Computed Tomography: Acquisition and Reconstruction

8. Tzschätzsch

Ultrasound elastography methods

9. Buchert

PET measured

water perfusion

10. Abram

Innovative radiotracers for PET

11. Schröder

CEST-MRI

12. Schäffter/Kolbitsch

Acceleration strategies for data sampling in MRI

13. Laufer

Photoacoustic tomography

PART III: Medical applications

14. Fischer, Thomas

Tumor characterization by ultrasound perfusion meas

urements and elastography

15. Schmitter

4D flow quantification in cardiovascular MRI

16. Schäffter

Cardiac perfusion MRI

17. Guo

Noninvasive assessment of pressure-related imaging parameters in portal hypertension

18. Dewey, Kachelrieß

Biophysical Parameters measured by dynamic computed tomography in the clinic

19. Brenner

Quan

tification of functional heterogeneities in tumors by PET imaging

20. Niendorf

Magnetic Resonance Myocardial Effective Transverse Relaxation Time at 7.0 Tesla for a Better Understanding of Myocardial (Patho)physiology.