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Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome.

The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

Cannabinoids and Sleep: Molecular, Functional and Clinical Aspects

Constituents of Cannabis Sativa.- Synthetic and Natural Derivatives of Cannabidiol.- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions.- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues.- Sleep-Wake Neurobiology.- Cannabinoids and Sleep/Wake Control.- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals.- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence.- Natural Cannabinoids as Templates for Sleep Disturbances Treatment.- The Effect of Cannabinoids on the Brain´s Circadian Clock.- Effects of Cannabis Consumption on Sleep.- Addiction and Sleep Disorders.- Cannabis for Restless Legs Syndrome.