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This text and the terminology developed by the Papanicolaou Society of Cytopathology (P.S.C.) represents an important advance in the field of pancreaticobiliary cytopathology. This textbook/atlas is designed to present a comprehensive and state of the art approach to the cytologic diagnosis and reporting of pancreaticobiliary lesions. Chapters address each of the diagnostic categories defined by the P.S.C. The definition of each category along with the clinical pathologic entities contained within the category are discussed along with specific cytologic criteria for inclusion of a cytologic specimen within the category. Each chapter is lavishly illustrated demonstrating diagnostic criteria and examples of lesions contained within the category. Additionally, appropriate ancillary testing is discussed and where appropriate illustrated. Each chapter concludes with a discussion of appropriate management as well as estimates of malignancy risk for the category.

The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria, Ancillary Testing and Management will provide the reader with a unified approach to diagnosing and reporting interpretations of cytologic specimens obtained from the pancreaticobiliary tract. This text/atlas will serve as a reference guide for pathologists, surgeons, endoscopists and radiologists.

The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology: Definitions, Criteria and Explanatory Notes

1. Overview of Diagnostic Terminology and Reporting



2. Category I. Non-Diagnostic



3. Category II. Negative (for Malignancy)



* Acute Pancreatitis



* Chronic Pancreatitis



* Autoimmune Pancreatitis



* Pseudocyst



* Lymphoepithelial Cyst



* Splenule/Accessory Spleen



4. Category III. Atypical



5. Category IV: Neoplastic: Benign



* Serous Cystadenoma



* Neuroendocrine Microadenoma



* Lymphangioma



6. Category IV: Neoplastic: Other



* Pancreatic Neuroendocrine Tumor



* Solid-Pseudopapillary Neoplasm



* Neoplastic Mucinous Cysts (Intraductal papillary mucinous neoplasm (IPMN) and Mucinous cystic neoplasm (MCN)



7. Category V. Suspicious (for Malignancy)



8. Category VI. Positive or Malignant



* Ductal adenocarcinoma and variants



* Acinar Cell Carcinoma



* High-grade neuroendocrine carcinoma



* Pancreatoblastoma



* Lymphoma



* Metastases



Appendix A: Template for Cyst Diagnosis



Appendix B: Mucinous Etiology



Appendix C: Useful Ancillary Tests