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This text is aimed at defining the current concepts that define trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It will serve as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader will have full understanding of the tests that are used to study trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications are reviewed in detail.
Trauma Induced Coagulopathy will also be a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy.

Trauma Induced Coagulopathy

Trauma Induced Coagulopathy

Eduardo Gonzalez, Hunter B. Moore, Ernest E. Moore

 

Table of Contents

 

·         Foreword

Kenneth Mann

 

·         Preface

Ernest E. Moore, Hunter B. Moore, Eduardo Gonzalez

 

·         Introduction: Historical Perspective: History of Trauma Induced Coagulopathy

Ernest E. Moore, Eduardo Gonzalez, Hunter B. Moore

 

 

Part 1: Physiology of Hemostasis

Chapter 1: Cell-Mediated Hemostasis

Maureane Hoffman

 

Chapter 2: Antithrombin Contributions to Physiological Hemostasis and Thrombosis Prevention, and its Dysregulation in Trauma and TIC

Susan C. Bock

 

Chapter 3: Physiology of Hemostasis: Plasmin-antiplasmin system

Nicola J Mutch, Nuala A Booth

 

 

Part 2: Pathogenesis of Trauma Induced Coagulopathy

Chapter 4: Thrombin Formation

Shekhar Kumar, Sriram Krishnaswamy

 

Chapter 5: Fibrinogen

Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore

 

Chapter 6: Activated Protein C

Mitchell Jay Cohen, Benjamin M. Howard

 

Chapter 7: Pathogenesis of Trauma Induced Coagulopathy: The Endothelium

Pär I. Johansson, Sisse R. Ostrowski

 

Chapter 8: Platelets

Scott L. Diamond

 

Chapter 9: Fibrinolysis

Hunter B. Moore, Ernest E. Moore, Eduardo Gonzalez

 

Chapter 10: Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy

Christopher D. Barrett, Michael B. Yaffe

 

Chapter 11: DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis

Charles T. Esmon

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Chapter 12: The Complement System and Coagulation

Narcis I. Popescu, Florea Lupu

 

Chapter 13: Disseminated Intravascular Coagulation

Satoshi Gando

 

 

Part 3: Coagulation Assessment in Trauma Induced Coagulopathy

Chapter 14: Prothrombin and Partial Thromboplastin Time

Ruchika Goel, Paul M Ness

 

Chapter 15: Fibrinogen Assays

Christoph J. Schlimp, Herbert Schöchl

           

Chapter 16: Platelet Aggregometry

Taizo Nakano, Jorge Di Paola

 

Chapter 17: Thrombelastography

Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore

 

Chapter 18: Rotational Thromboelastometry (ROTEM®)

Klaus Görlinger, Daniel Dirkmann, Alexander A. Hanke

 

 

Part 4: Management of Trauma Induced Coagulopathy

Chapter 19: Red Blood Cell: Manufacture, Storage, and Transfusion

F. Bernadette West, Marguerite R. Kelher, Christopher C. Silliman

 

Chapter 20: Plasma Transfusion

Ryan A. Lawless, John B. Holcomb

 

Chapter 21: Cryoprecipitate Transfusion

Jeannie L. Callum, Bartolomeu Nascimento

 

Chapter 22: The Evolving Role of Platelets in Trauma Care

Andrew P. Cap, Todd Getz, Philip Spinella, Heather Pidcoke

 

Chapter 23: Massive Transfusion Protocols

Alexis M. Moren, Samantha J. Underwood, Martin A. Schreiber

 

Chapter 24: Fibrinogen and Clotting Factor Replacement

Massimo Franchini

 

Chapter 25: Anti-Fibrinolytics

Dominik F. Draxler, Robert L. Medcalf, Russell L. Gruen

 

 

Part 5: Post-injury Hypercoagulability

Chapter 26: Venous Thromboembolism

Steven R. Shackford, C. Beth Sise

 

Chapter 27: Congenital and Acquired Hypercoagulable States

Joseph Emmerich

 

 

Part 6: Organ-specific Coagulopathy

Chapter 28: Coagulopathy in Traumatic Brain Injury (TBI)

Marc Maegele

 

Chapter 29: Liver Disease

Shahzaib Ahmad, Beverly J Hunt

 

Chapter 30: Hemostatic Abnormalities in Renal Disease

Michael P. Chapman, Anirban Banerjee, Ernest E. Moore

 

 

Part 7: Trauma Induced Coagulopathy in Special Populations

Chapter 31: Pediatrics

Robert I. Parker

 

Philippe de Moerloose, T. Marchetti, A. Casini

 

Chapter 33: Management of Chronically Anticoagulated Patients

Jerrold H. Levy

 

 

Part 8: Research of Trauma Induced Coagulopathy

Chapter 34: Animal Models

Ted Bambakidis, Martin Sillesen, Hasan B. Alam

 

Chapter 35: Mathematical Models of Hemostasis

Keith B. Neeves, Karin Leiderman