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The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.

Personalised Medicine: Lessons from Neurodegeneration to Cancer

Preface - Personalised Medicine: Lessons from Neurodegenration to Cancer, Sherif F. El-Khamisy.- chap. 1 Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair, Dean T. Williams et al.- chap. 2 Nucleotide excision repair: from neurodegeneration to cancer, Liakos et al.- chap. 3 The Role of Protein-Linked DNA Breaks in Personalized Medicine Walaa R. et al.- chap. 4 The Emerging Role of Proteomics in Precision Medicine: Application in Neurodegenerative Diseases and Neurotrauma, Rana Alaaeddine et al.- chap. 5 The Role of Nitric Oxide from Neurological Disease to Cancer, Ahmed Maher et al.- chap. 6 RNA nuclear export: from neurological disorders to cancer, Guillaume M. Hautbergue.- chap. 7. Can astrocytes be a target for precision medicine, Chloe Allen et al.- chap. 8 Mitochondrial Diseases as Model of Neurodegeneration, Laila A. Selim et al.- chap. 9 Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism, Arwa A. Abugable et al.- chap. 10 The Power of Zebrafish in Personalised Medicine, Sarah Baxendale et al.- chap. 11 Alzheimer's Disease: a Modular Approach Based on GSK-3beta Inhibitors Reem k. Arafa et al.- chap. 12. Regenerative medicine: advances from developmental to degenerative diseases, Nicholas F. Blair et al.- chap. 13 Gene therapy in the nervous system: failures and successes, Jayanth S. Chandran et al.- index.