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This textbook presents a broad overview of topics concerning cellular electrophysiology - covering topics ranging from bioelectric phenomena recognized as far back as ancient Egypt to popular topics on the dangers of electrosmog. Without sacrificing scientific precision, this clear and concise work presents on the one hand the different methods and applications, on the other hand the biophysical fundamentals of ion-channel and carrier proteins. Numerous and carefully selected illustrations and diagrams supplement the text, while questions at the end of each chapter allow readers to test their understanding. Each section also includes references to relevant original literature for further reading. The book offers a valuable resource for students of biology, chemistry and physics with a special interest in biophysics.

Electrophysiology: Basics, Modern Approaches and Applications

Chapter 11     Introduction1.1   INTRODUCTORY OVERVIEW1.2   HISTORY OF ELECTROPHYSIOLOGY
Chapter 22     Basics: Theory2.1   ELECTRICAL CHARACTERISTICS OF BIOLOGICAL MEMBRANES2.2   ION DISTRIBUTION AT BIOLOGICAL MEMBRANES2.3   DONNAN DISTRIBUTION AND NERNST EQUATION2.4   GOLDMAN-HODGKIN-KATZ EQUATION
Chapter 33.    Basics: Methods3.1   RECORDING ELECTRICAL SIGNALS FROM BODY SURFACE3.2   THE EXAMPLE (ECG)3.3   RECORDING ELECTRICAL SIGNALS FROM TISSUE3.4   RECORDING ELECTRICAL SIGNALS FROM SINGLE CELLS3.5   APPLICATION OF THE VOLTAGE-CLAMP TECHNIQUE3.6   THE PATCH-CLAMP TECHNIQUE
Chapter 44     Automated Electrophysiology4.1   AUTOMATED TWO-ELECTRODE VOLTAGE CLAMP4.2   AUTOMATED PATCH CLAMP
Chapter 55     Ion-selective Channels5.1   GENERAL CHARACTERISTICS OF ION CHANNELS5.2   SPECIFIC ION CHANNELS
Chapter 66     Theory of Excitability6.1   THE HODGKIN-HUXLEY DESCRIPTION OF EXCITATION6.2   CONTINUOUS AND SALTATORY CONDUCTION OF ACTION POTENTIALS6.3   GENERATION AND TRANSMISSION OF ACTION POTENTIALS6.4   SUMMARY OF THE DIFFERENT TYPES OF POTENTIALS6.5   ACTION POTENTIAL IN NON-NERVE CELLS
Chapter 77     Carrier-mediated Transport7.1   GENERAL CHARACTERISTICS OF CARRIERS7.2   CARRIERS ARE LIKE CHANNELS WITH ALTERNATING GATES
Chapter 88     Examples of Application of Electrophysiology8.1   STRUCTURE-FUNCTION RELATIONSHIPS OF CARRIER PROTEINS8.2   STRUCTURE-FUNCTION RELATIONSHIPS OF ION CHANNELS8.3   VIRAL ION CHANNELS
AppendixA1.   THE GRAPH THEORYA2.   INFLUENCE OF EXTERNAL ELECTRICAL AND MAGNETIC FIELDS A2.1. MAGNETOSTATIC FIELDSA3.   A LABORATORY COURSE:
Important Physical UnitsList of Symbols and AbbreviationsIndex