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The only topical HPLC book to focus on optimization, this volume addresses the needs of HPLC users who wish to constantly improve their methods, in particular in terms of throughput, accuracy and cost-effectiveness.This handbook features contributions from such bestselling authors as John W. Dolan, Michael McBrien, Veronika R. Meyer, Uwe D. Neue, Lloyd R. Snyder, and Klaus K. Unger, as well as from scientists working for major companies, including Agilent, AstraZeneca, Merck, Schering, Tosoh Biosep, VWR, and Waters. It covers essential aspects of optimization in general, optimization in different LC-modi, hyphenated techniques and computer-aided optimization. The whole is rounded off with a section of user reports.

HPLC Made to Measure: A Practical Handbook for Optimization

ESSENTIAL ASPECTS OF OPTIMIZATIONPrinciples of HPLC Optimization Illustrated by RP-ChromatographyFast Gradient SeparationspH and Selectivity in Reversed-Phase ChromatographySelecting the Correct pH-Value for HPLCOptimization of Data Evaluation in ChromatographyCalibration Characteristics and Uncertainty indicating Starting-Points for Method OptimizationOPTIMIZATION IN DIFFERENT LC-MODIComparison and Choice of Columns for RP-HPLCColumn Selectivity in Reversed-Phase ChromatographyThe Use of Principal Component Analysis for the Characterisation of Reversed-Phase Liquid Chromatographic Stationary PhasesChemometrics - A Powerful Tool for Handling a Large Number of DataLinear Free Energy Relations - Tools for Column Characterization and Method Optimization in HPLC?Column Selectivity in Reversed-Phase Liquid ChromatographyUnderstanding Selectivity by Use of Suspended-State High Resolution Magic Angle Spinning NMR SpectroscopyOptimization in Normal-Phase HPLCOptimization of GPC/SEC Separations by Proper Selection of Stationary Phase and DetectionGel Filtration - Size Exclusion Chromatography of biopolymersOptimization in Affinity ChromatographyOptimization of Chiral Separations in HPLCµLC/nano LC - Optimization and TroubleshootingMicrochip-Based Liquid Chromatography - Techniques and PossibilitiesUltra-Performance Liquid ChromatographyHYPHENATED TECHNIQUESImmunochromatographic TechniquesEnhanced Characterization and Comprehensive Analyses by 2-dimensional ChromatographyLC/MS - Hints and Recommendations for Optimization and TroubleshootingLC-NMR-CouplingCOMPUTER-AIDED OPTIMIZATIONComputer-Facilitated HPLC Method Development Using DryLab SoftwareChromSword Software for Automated and Computer-Assisted Development of HPLC MethodsMultifactorial Systematic Method Development and Optimization in Reversed Phase HPLCUSER REPORTSNanoLC-MS/MS in ProteomicsWays for the Verification of the Robustness in RP-HPLCSeparation of Complex Sample MixturesEvaluation of an integrated procedure for the characterization of chemical libraries on the basis of HPLC-UV/MS/CLND