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Covering aspects of molecular mechanisms in tumor angiogenesis, anti-angiogenic targeting plus therapeutic combinations with established treatments, this is an ideal reference for students, graduate scientists and medics, as well as those working in the pharmaceutical industry.

Tumor Angiogenesis From Molecular Mechanisms to Targeted The

INTRODUCTION Overview on Tumor Angiogenesis (Donati, Lorenzet) MECHANISMS OF ANGIOGENESIS AND LYMPHANGIOGENESIS Molecular Mechanisms of Angiogenesis (Dudley, Claesson-Welsh) Pro-angiogenic Factors (Ribatti) The Role of Accessory Cells in Tumor Angiogenesis (Takakura) Comparison between Developmental and Tumor Angiogenesis (Bikfalvi) Tumor Lymphangiogenesis (Ramu, Hong) SIGNAL TRANSDUCTION AND ANGIOGENESIS Integrin Involvement in Angiogenesis (Akalu, Contois, Brooks) Signaling Pathways in Tumor Angiogenesis (Abrahams, Daly, Eichten, Li, Noguera-Troise, Thurston) THERAPEUTIC APPROACHES AND ANGIOGENESIS Development of an Integrin Targeted Anti-Angiogenic Agent (Swenson, Minea, Markland) Anti-VEGF Approaches and Newer Antiangiogenic Agents (including combrestatins) which are already in Clinical (Libutti) Combination of Antiagiogenic Therapy with Other Anticancer Therapies (Gasparini) Tumor specificity of anti-angiogenic agents (Rixe, Kelly, Giaccone) IMAGING AND BIOMARKERS IN ANGIOGENESIS In vivo imaging of tumor angiogenesis (Turkbey, Ravizzini, Choyke) Identifying Biomarkers to Establish Drug Efficacy (Platero)