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A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people.Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization's list of neglected tropical diseases. The authors - all are experts on the topic - address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world's popluation.The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book:- Ties together information from different sources for developing novel treatsments forneglected tropical diseases - Is aligned with WHO's initiative to eradicate tropical diseases- Outlines current and potential drugs for treating tropical diseases- Provides a standard reference for the entire fieldWritten for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Neglected Tropical Diseases: Drug Discovery and Development

INTRODUCTIONDrug Discovery Strategies for Neglected Tropical DiseasesPART I: VIRUSESTowards Antiviral Therapies for the Treatment of Zika Virus InfectionDeveloping Therapeutics for Ebola Virus DiseasePART II: KINETOPLASTSDesigning drugs to target Trypanosoma cruzi, the etiological agent of Chagas diseaseDrug Discovery and Development for human African trypanosomiasisDrug Discovery and development for LeishmaniasisPART III. HELMINTHIC PARASITESOnchocerciasis Drug DiscoveryDrug Discovery and Development for Schistosomiasis Soil transmitted helminthiasis - challenges with discovery of novel anthelmintics Drug discovery and development for the treatment of EchinococcosisNew insights in the treatment of foodborne trematode InfectionsPART IV: BACTERIABuruli ulcerDrug Discovery and Development for Leprosy