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The Pattern Recognition in Bioinformatics (PRIB) meeting was established in 2006 under the auspices of the International Association for Pattern Recognition (IAPR) to create a focus for the development and application of pattern recognition techniques in the biological domain. PRIB s aim to explore the full spectrum of pattern recognition application was re?ected in the breadth of techniquesrepresented in this year s subm- sions and in this book. These range from image analysis for biomedical data to systems biology. We werefortunatetohaveinvitedspeakersofthehighestcalibredeliveringkeynotes at the conference. These were Pierre Baldi (UC Irvine), Alvis Brazma (EMBL-EBI), GunnarRats ch(MPITubi ngen)andMichaelUnser(EPFL).Weacknowledgesupportof theEUFP7NetworkofExcellencePASCAL2forpartiallyfundingtheinvitedspeakers. Immediately prior to the conference, we hosted half day of tutorial lectures, while a special session on Machine Learningfor IntegrativeGenomics was held immediately after the main conference.Duringthe conference,a poster session was heldwith further discussion. Wewouldlikeonceagaintothankalltheauthorsforthehighqualityofsubmissions, as well as Yorkshire South and the University of Shef?eld for providing logistical help in organizing the conference. Finally, we would like to thank Springer for their help in assembling this proceedings volume and for the continued support of PRIB.

Pattern Recognition in Bioinformatics: 4th IAPR International Conference, PRIB 2009, Sheffield, UK, September 7-9, 2009, Proceedings