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This volume provides a comprehensive overview of the development, pharmacology, efficacy, and safety of the currently available TNF-alpha inhibitors. It is the first volume that summarizes this material for all available TNF-alpha inhibitors. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis, suggesting a role for TNF-alpha in their pathogenesis. The most recent preclinical and clinical data is presented in this book.

TNF-alpha Inhibitors

Preface.- Introduction to TNF/Pathophysiology of TNF.- History of development of TNF inhibitors.- Pharmacology of TNF inhibitors.- Etanercept in rheumatology.- Etanercept in dermatology and off-label use.- Infliximab in rheumatology.- Infliximab in dermatology, gastroenterology and off-label use.- Adalimumab in rheumatology.- Adalimumab in dermatology.- A review of the safety of the tumor necrosis inhibitors infliximab, etanercept, and adalimumab.