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This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.

Serotonin and Sleep: Molecular, Functional and Clinical Aspects

Changing concepts on the role of serotonin in the regulation of sleep and waking.- Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus.- Efferent and afferent connections of the dorsal and median raphe nuclei in the rat.- Reciprocal connections between the suprachiasmatic nucleus and the midbrain raphe nuclei: a putative role in the circadian control of behavioral states.- Localization of 5-HT receptors in the mammalian cortex.- Molecular biology of 5-HT receptors.- Brain serotonergic neuronal activity in behaving cats.- Electrophysiological studies of serotonergic neurons and sleep.- Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons.- Regulation of serotonin release by inhibitory and excitatory amino acids.- Neurophysiological aspects of the regulation of serotonin neurons by the orexinergic system.- Serotonin and dreaming.- Involvement of the 5-HT1A and the 5-HT1B receptor in the regulation of sleep and waking.- Mechanisms involved in the inhibition of REM sleep by serotonin.- Effect of 5-HT2A/2B/2C receptor agonists and antagonists on sleep and waking in laboratory animals and humans.- Effect of the selective activation of serotonin 5-HT3 receptors on sleep and waking.- 5-HT7 receptor modulation of sleep patterns.-Sleep and waking in mutant mice that do not express various proteins involved in serotonergic neurotransmission such as the serotonergic transporter, monoamine oxydase A, and 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT7 receptors.- Circadian control by serotonin and melatonin receptors: clinical relevance.- Serotonergic mechanisms contributing to arousal and alerting.- Contribution of chemosensitive serotonergic neurons to interactions between the sleep-wake cycle and respiratory control.- Obstructive sleep apnea: the potential for serotonergic pharmacotherapies.- The effects of antidepressant drugs and 5HT1A agonists on human sleep.- Theeffect of typical and atypical antipsychotic drugs on sleep of schizophrenic patients.