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This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices.  It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening.  Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Microfluidics and Multi Organs on Chip

Chapter 1. A Historical and Technological Background to Organs-on-a-Chip.- Chapter 2. Applications of microfluidics.-  Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies.-  Chapter 4. Microfluidics in Chemical biology.- Chapter 5. Role of microfluidics in drug delivery.-  Chapter 6. Microfluidics in drug discovery.- Chapter 7. Microfludic based sensors.- Chapter 8. Background and Organs-on-a-Chip.- Chapter 9. Culture and co-culture of cells for multi organ on chip.-  Chapter 10.Cells and organs on a chip in biomedical sciences.- Chapter 11. Futuristic aspects of organ on a chip.- Chapter 12. Development of Human on a chip.- Chapter 13. Multi-organ on a chip for personalized medicine.- Chapter 14. Development and application of Microfluids in organoid formation.-  Chapter 15. Liver on a chip.-  Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface.- Chapter 17. Microfluidic retina-on-chip.- Chapter 18. Heart on a chip.- Chapter 19. Kidney on a chip.-  Chapter 20. Lungs on a chip.-  Chapter 21. Brain on a chip.-  Chapter 22. Skin on a chip.-  Chapter 23. Organs-on-a-chip in preclinical studies.- Chapter 24. Application of organ on chip in blood brain barrier model.- Chapter 25. Multi organs on a chip in disease modeling.-  Chapter 26. Prospects of Medical device on a chip.- Chapter 27. Lab on a chip for precision Medicine.- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation.- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.