In the present thesis, a possible block in the sterol pathway to facilitate 2,3-oxidosqualene accumulation was investigated. Several truncated versions of a previous ERG7 modification were tested for triterpenoid synthesis in a strain that was modified for increased flux through the mevalonate pathway.In summary, the chassis combined with the mineral medium provides a complete solution for high-level production of diverse triterpenoids, overcoming the main hurdles of translation of these potent natural products into industry, availability and high price.
Optimization of triterpenoid production in engineered Saccharomyces cerevisiae
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